Episode #1234
David Sinclair
Books mentioned
The Structure of Scientific Revolutions
Mentioned by David Sinclair · at 01:58:40
Amazon (opens in a new tab; affiliate link) Source: Transcript (podscripts.co)
Timestamps are segment start times from the podscripts.co transcript of the audio release (includes ad reads), so they may differ from the video by a few minutes.
David Sinclair, a Harvard Medical School genetics professor and aging researcher, discusses how cellular reprogramming may repair damaged tissues and how epigenetic changes contribute to aging. The episode explores fasting, diet, exercise, supplements, gene editing, microbiome research, diagnostics, and the scientific, ethical, economic, and geopolitical challenges of extending human life.
What they talked about
- Intermittent fasting and calorie restriction for longevity
- Metformin as an off-label anti-aging drug
- Three key longevity pathways: AMPK, sirtuins, mTOR
- Trade-off between growth and long-term health (disposable soma theory)
- DNA damage and epigenetic aging (the scratched DVD analogy)
- Gene therapy to reverse blindness in mice
- Lyme disease diagnosis using DNA sequencing
- Scientific controversy and resilience in aging research
Data last updated · Report a mistake · How it works: mentions are pulled from public transcripts and episode descriptions, partly with AI-assisted extraction, so details and timestamps can be off.