Episode #1349
David Sinclair
Books mentioned
Lifespan
Mentioned by Speaker not yet confirmed · at 00:00:00
Amazon (opens in a new tab; affiliate link) Source: Official episode description (podcast RSS) · Transcript (podscripts.co)
Timestamps are segment start times from the podscripts.co transcript of the audio release (includes ad reads), so they may differ from the video by a few minutes.
Harvard geneticist David Sinclair discusses the biology of aging, including NAD-related compounds, epigenetic change, partial reprogramming, senolytics, and regenerative gene therapies. He and Joe Rogan also examine fasting, exercise, diet, preventive medicine, clinical uncertainty, and how emerging technologies may address age-related diseases and extend healthy lifespan.
What they talked about
- Metformin, DHEA, and HGH study reversing biological age
- NAD, sirtuins, and NMN as anti-aging molecules
- Pulsing exercise and fasting for longevity
- Hot and cold therapy for health
- David Sinclair's Africa trip and pygmy charity
- Zombie cells and cellular reprogramming
- Caloric restriction and intermittent fasting
- Reprogramming factors to reverse vision loss
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